| 1. Identity statement | ||||
| Reference Type | Journal Article | |||
| Holder Code | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Site | mtc-m21d.sid.inpe.br (namespace prefix: upn:44QHRCS) | |||
| Identifier | 8JMKD3MGP3W34T/475K3LL | |||
| Repository | sid.inpe.br/mtc-m21d/2022/06.20.18.48 (restricted access) | |||
| Last Update | 2022:06.20.18.48.21 (UTC) simone | |||
| Metadata Repository | sid.inpe.br/mtc-m21d/2022/06.20.18.48.21 | |||
| Metadata Last Update | 2023:01.03.16.46.07 (UTC) administrator | |||
| DOI | 10.1016/j.saa.2022.121407 | |||
| ISSN | 1386-1425 | |||
| Citation Key | WeinandCMLSPGVRSRBBSSSGQCNHBM:2022:DyNaGe | |||
| Title | Dynamics of the natural genesis of β-TCP/HAp phases in postnatal fishbones towards gold standard biocomposites for bone regeneration  | |||
| Year | 2022 | |||
| Month | Oct. | |||
| Access Date | 2026, Oct. 18 | |||
| Type of Work | journal article | |||
| Secondary Type | PRE PI | |||
| Number of Files | 1 | |||
| Size | 4327 KiB | |||
| 2. Context | ||||
| Author | 1 Weinand, Wilson Ricarco 2 Cruz, José Adauto 3 Medina, Antonio Neto 4 Lima, Walter Moreira 5 Sato, Francielle 6 Palacios, Raquel da Silva 7 Gibin, Mariana Sversut 8 Volnistem, Eduardo Azzolini 9 Rosso, Jaciele Marcia 10 Santos, Ivair Aparecido 11 Rohling, Jurandir Hillmann 12 Bento, Antonio Carlos 13 Baesso, Mauro Luciano 14 Silva, Camila Girotto da 15 Santos, Erika Xavier dos 16 Scatolim, Douglas Bolzon 17 Gavazzoni, Alessandro 18 Queiroz, Alfredo Franco 19 Campanhoni, Mychelle Vianna Pereira 20 Nakamura, Tania Ueda 21 Hernandes, Luzmarina 22 Bonadio, Taiana Gabriela Moretti 23 Miranda, Luís Carlos Moura | |||
| Group | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 COPDT-CGIP-INPE-MCTI-GOV-BR | |||
| Affiliation | 1 Universidade Estadual de Maringá (UEM) 2 Universidade Estadual de Maringá (UEM) 3 Universidade Estadual de Maringá (UEM) 4 Universidade Estadual de Maringá (UEM) 5 Universidade Estadual de Maringá (UEM) 6 Universidade Estadual de Maringá (UEM) 7 Universidade Estadual de Maringá (UEM) 8 Universidade Estadual de Maringá (UEM) 9 Universidade Estadual de Maringá (UEM) 10 Universidade Estadual de Maringá (UEM) 11 Universidade Estadual de Maringá (UEM) 12 Universidade Estadual de Maringá (UEM) 13 Universidade Estadual de Maringá (UEM) 14 Universidade Estadual de Maringá (UEM) 15 Universidade Estadual de Maringá (UEM) 16 Universidade Estadual de Maringá (UEM) 17 Universidade Estadual de Maringá (UEM) 18 Universidade Estadual de Maringá (UEM) 19 Universidade Estadual de Maringá (UEM) 20 Universidade Estadual de Maringá (UEM) 21 Universidade Estadual de Maringá (UEM) 22 Universidade Estadual do Centro Oeste 23 Instituto Nacional de Pesquisas Espaciais (INPE) | |||
| Author e-Mail Address | 1 2 3 4 5 6 7 8 9 10 11 12 13 mlbaesso@uem.br | |||
| Journal | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | |||
| Volume | 279 | |||
| Pages | e121407 | |||
| Host Collection | urlib.net/www/2021/06.04.03.40 upn:44QHRCS | |||
| History (UTC) | 2022-06-20 18:50:25 :: simone -> administrator :: 2022 2023-01-03 16:46:07 :: administrator -> simone :: 2022 | |||
| 3. Content and structure | ||||
| Is the master or a copy? | is the master | |||
| Content Stage | completed | |||
| Transferable | 1 | |||
| Content Type | External Contribution | |||
| Version Type | publisher | |||
| Keywords | Biphasic calcium phosphate Bone regeneration Fishbone Genesis of the β -TCP/HAp phases β -tricalcium phosphate | |||
| Abstract | The search for gold-standard materials for bone regeneration is still a challenge in reconstruction surgery. The ratio between hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) in biphasic calcium phosphate ceramics (BCPs) is one of the most important factors in osteoinduction promotion and controlled biodegradability, configurating what is currently considered as a possible gold standard material for bone substitution in reconstructive surgery. Exploring the natural genesis of the HAp and β-TCP phases in fishbones during their postnatal growth, this study developed a biphasic bioceramic obtained from the calcination of Nile tilapia (Oreochromis niloticus) bones as a function of their ages. The natural genesis dynamics of the structural evolution of the β-TCP and HAp phases were characterized by physicochemical methods, taking into account of the age of the fish and the material processing conditions. Thermal analysis (TGA / DTA) showed complete removal of the organic matter and transitions associated with the transformation of carbonated hydroxyapatite (CDHA) to HAp and β-TCP phases. After calcination at 900 °C, the material was characterized by: X-ray diffraction (XRD) and refinement by the Rietveld method; Fourier Transform Infrared Spectroscopy with Attenuated Total Reflection (FTIR-ATR); Raman spectroscopy; Scanning Electron Microscopy (SEM) and Flame Atomic Absorption Spectroscopy (FAAS). The analysis allowed identification and quantitative estimate of the variations of the HAp and β-TCP phases in the formation of the BCPs. The results showed that the decrease in β-TCP against the increase in the HAp phases is symmetrical to the dynamics of the natural genesis of these phases, surprisingly maintaining the balanced phase proportion even when bones of young fishes were used. The microstructure analysis confirms the observed transformation. In addition, in vivo tests demonstrated the osteoinductive potential of BCP scaffolds implanted in an ectopic site, and their remarkable regenerative functionality, as bone graft, was demonstrated in alveolar bone after tooth extraction. MTT cytotoxicity assay for BCP samples for MC3T3-E1 pre-osteoblasts and L929 fibroblasts cells showed viability equal or higher than 100%. A logistic empirical model is presented to explain the three stages of HAp natural formation with fish age and it is also compared to the fish size evolution. | |||
| Area | FISMAT | |||
| Arrangement | urlib.net > BDMCI > Fonds > Produção a partir de 2021 > CGIP > Dynamics of the... | |||
| doc Directory Content | access | |||
| source Directory Content | there are no files | |||
| agreement Directory Content |
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| 4. Conditions of access and use | ||||
| Language | en | |||
| Target File | 1-s2.0-S138614252200556X-main.pdf | |||
| User Group | simone | |||
| Reader Group | administrator simone | |||
| Visibility | shown | |||
| Read Permission | deny from all and allow from 150.163 | |||
| Update Permission | not transferred | |||
| 5. Allied materials | ||||
| Next Higher Units | 8JMKD3MGPCW/46KUES5 | |||
| Citing Item List | sid.inpe.br/bibdigital/2022/04.03.23.11 - 74 | |||
| Dissemination | WEBSCI; PORTALCAPES; SCOPUS. | |||
| 6. Notes | ||||
| Empty Fields | alternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress format isbn label lineage mark mirrorrepository nextedition notes number orcid parameterlist parentrepositories previousedition previouslowerunit progress project resumeid rightsholder schedulinginformation secondarydate secondarykey secondarymark session shorttitle sponsor subject tertiarymark tertiarytype url | |||
| 7. Description control | ||||
| e-Mail (login) | simone | |||
| update | ||||